Be sure to check out the "Inside the Play" analysis of the stop on 4th-and-1 versus Ole Miss. Ultimately, though, Staples sums up why it takes a perfect storm to stop him:
To truly contain Tebow, you'll need to force Meyer to make his star carry more than 15 times, spy him with a 290-pound former kick returner and use your future first-round defensive tackle to stuff him on fourth-and-one with the game on the line. This plan is completely foolproof. It can't fail.